Product ID:ESI 76380,NDC 00641-2548-41
MSDS Date:03/24/1993
FSC:6505
NIIN:00-958-6325
MSDS Number: BZLJG

ELKINS-SINN INC

2 ESTERBROOK LN
CHERRY HILL, NJ 08003
US

Emergency Phone: 215-688-4400/800-424-9300 (CHEMTRAC

Info Phone: 609-424-3700/800-257-8349

Cage: 51968

ELKINS-SINN INC

CHERRY HILL, NJ 08003-4099 US

Telephone: 800-257-8349/609-424-3700

Cage: 51968

NEOSTIGMINE METHYLSULFATE

CAS: 51-60-5

RTECS: CY1225000

Fraction By Weight: .05-0.1%

WATER

CAS: 7732-18-5

RTECS: ZC0110000

Fraction By Weight: >16%

OSHA PEL NOT RELEVANT

ACGIH TLV: NOT RELEVANT

LD50 LC50 Mixture:LD50 (ORAL, MOUSE) IS 7500 UG/KG.
Routes of Entry: Inhalation:YES Skin:YES Ingestion:YES
Reports of Carcinogenicity:NTP:NO IARC:NO OSHA:NO
Health Hazards Acute and Chronic:TARGET ORGANS:EYE, SKIN, CNS,
RESPIRATORY & GI TRACTS. ACUTE & CHRONIC- FOR THERAPEUTIC USE ONLY
WHEN PRESCRIBED BY A PHYSICIAN. INHALATION/INGESTION/SKIN
ABSORPTION MAY CAUSE CHOLINESTERASE INHIBITIO N. MAY CAUSE CNS
EFFECTS, PARALYSIS OF RESPIRATORY MUSCLE, COMA, CONVULSION,
PULMONARY EDEMA, HYPOTENSION, DEATH.
Explanation of Carcinogenicity:NONE
Effects of Overexposure:DROWSINESS, DRYNESS OF MOUTH, COMA, CHEST
TIGHTNESS, NAUSEA, VOMITING, DIARRHEA, HEADACHE, EYE PAIN, BLURRED
VISION, SALIVATION, SWEATING, CONFUSION, INVOLUNTARY DEFECATION AND
URINATION, CONVULSION, COMA, CARDIAC ARREST, DEATH
Medical Cond Aggravated by Exposure:INDIVIDUALS WITH PRE-EXISTING
DISEASES OF THE EYE, SKIN, RESPIRATORY TRACT, HEART, CNS MAY HAVE
INCREASED SUSCEPTIBILITY TO THE TOXICITY OF EXCESSIVE EXPOSURES.

First Aid:CALL PHYSICIAN IF SYMPTOMS PERSIST. EYE:IMMEDIATELY FLUSH
WITH WATER FOR 15 MINUTES. HOLD EYELIDS OPEN. CALL PHYSICIAN.
SKIN:WASH WITH SOAP & WATER. INHALED:REMOVE TO FRESH AIR. PROVIDE
CPR/OXYGEN IF NEEDED. ORAL:IF CONSCIOUS, INDUCE VOMITING (IPECAC
SYRUP+WATER). CALL A PHYSICIAN/POISON CONTROL CENTER IMMEDIATELY.
NEVER GIVE FLUID OR INDUCE VOMITING IF PATIENT IS UNCONSCIOUS OR
HAS CONVULSIONS.

Flash Point:NONE
Extinguishing Media:WATER SPRAY, CARBON DIOXIDE, FOAM OR DRY CHEMICAL
FOR SURROUNDING FIRE. USE WATER SPRAY TO COOL FIRE EXPOSED
CONTAINERS.
Fire Fighting Procedures:WEAR PROTECTIVE CLOTHING AND NIOSH-APPROVED
SELF-CONTAINED BREATHING APPARATUS. SEE 1990 EMERGENCY RESPONSE
GUIDEBOOK, DOT P 5800.5.
Unusual Fire/Explosion Hazard:NEGLIGIBLE FIRE HAZARD.

Spill Release Procedures:WEAR PROTECTIVE EQUIPMENT. ABSORB SPILL WITH
VERMICULITE OR OTHER INERT MATERIAL. PLACE IN A CONTAINER FOR
CHEMICAL WASTE. CLEAN AREA WITH SOAP AND WATER.
Neutralizing Agent:NOT RELEVANT

Handling and Storage Precautions:STORE AWAY FROM INCOMPATIBLE
MATERIALS. KEEP OUT OF REACH OF CHILDREN.
Other Precautions:VERY TOXIC. AS A GENERAL RULE, WHEN HANDLING
PHARMACEUTICAL PRODUCTS, AVOID ALL FORMS OF CONTACT AND INHALATION
OF DUST, FUMES, MISTS, AND/OR VAPORS ASSOCIATED WITH THE PRODUCT.
WASH THOROUGHLY AFTER HANDLING AND BEFORE EATING OR DRINKING.

Respiratory Protection:IF ENGINEERING CONTROLS DO NOT MAINTAIN AIRBORNE
CONCENTRATIONS TO AN ACCEPTABLE LEVEL, A NIOSH-APPROVED RESPIRATOR
MUST BE WORN. IN EMERGENCY, USE SELF-CONTAINED BREATHING APPARATUS.
Ventilation:USE GENERAL OR LOCAL EXHAUST VENTILATION TO KEEP FUME OR
DUST LEVELS AS LOW AS POSSIBLE.
Protective Gloves:LATEX
Eye Protection:SAFETY GLASSES/CHEMICAL SPLASH GOGGLES
Other Protective Equipment:SAFETY SHOWER AND EYE WASH FOUNTAIN SHOULD
BE LOCATED NEARBY. WEAR APPROPRIATE PROTECTIVE CLOTHING FOR RISK OF
EXPOSURE.
Work Hygienic Practices:OBSERVE GOOD PERSONAL HYGIENE PRACTICES AND
RECOMMENDED PROCEDURES. DO NOT WEAR CONTAMINATED CLOTHING.
Supplemental Safety and Health
ANTIDOTE:ASSIST PULMONARY VENTILATION WITH OXYGEN. ADMINISTER ATROPINE
SULFATE INTRAVENOUSLY/INTRAMUSCULARLY, 0.4-2 MG REPEATED EVERY 15
MINUTES UNTIL ATROPINIZATION IS ACHIEVED (TACHYCARDIA, FLUSHING ,
DRY MOUTH). REPEAT IF NECESSARY FOR 2-12 HOURS OR LONGER. PERSON
NOT POISONED, MAY DEVELOP SIGNS OF ATROPINE TOXICITY.

HCC:N1
NRC/State Lic Num:NOT RELEVANT
Boiling Pt:B.P. Text:212F,100C
Spec Gravity:1.0
Solubility in Water:SOLUBLE
Appearance and Odor:CLEAR, COLORLESS SOLUTION

Stability Indicator/Materials to Avoid:YES
ACIDS, BASES, OXIDIZERS
Stability Condition to Avoid:EXCESSIVE HEAT
Hazardous Decomposition Products:MAY FORM TOXIC AND/OR HAZARDOUS GASES.
Conditions to Avoid Polymerization:EXCESSIVE HEAT

Waste Disposal Methods:DISPOSE OF IN ACCORDANCE WITH ALL LOCAL, STATE
AND FEDERAL REGULATIONS.

Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.